Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
About this item
Full title
Author / Creator
Wu, Xueling , Yang, Zhi-Yong , Li, Yuxing , Hogerkorp, Carl-Magnus , Schief, William R , Seaman, Michael S , Zhou, Tongqing , Schmidt, Stephen D , Wu, Lan , Xu, Ling , Longo, Nancy S , McKee, Krisha , O'Dell, Sijy , Louder, Mark K , Wycuff, Diane L , Feng, Yu , Nason, Martha , Doria-Rose, Nicole , Connors, Mark , Kwong, Peter D , Roederer, Mario , Wyatt, Richard T , Nabel, Gary J and Mascola, John R
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Cross-reactive neutralizing antibodies (NAbs) are found in the sera of many HIV-1-infected individuals, but the virologic basis of their neutralization remains poorly understood. We used knowledge of HIV-1 envelope structure to develop antigenically resurfaced glycoproteins specific for the structurally conserved site of initial CD4 receptor bindin...
Alternative Titles
Full title
Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
Authors, Artists and Contributors
Author / Creator
Yang, Zhi-Yong
Li, Yuxing
Hogerkorp, Carl-Magnus
Schief, William R
Seaman, Michael S
Zhou, Tongqing
Schmidt, Stephen D
Wu, Lan
Xu, Ling
Longo, Nancy S
McKee, Krisha
O'Dell, Sijy
Louder, Mark K
Wycuff, Diane L
Feng, Yu
Nason, Martha
Doria-Rose, Nicole
Connors, Mark
Kwong, Peter D
Roederer, Mario
Wyatt, Richard T
Nabel, Gary J
Mascola, John R
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2965066
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2965066
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1187659
