Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Could similar changes in SOD1 underlie both familial and sporadic ALS? Here, Bosco
et al
. find that wild-type SOD1 from sporadic ALS tissues shows conformational changes similar to those seen in familial ALS and that aberrant wild-type SOD1 can be pathogenic, potentially as a result of the same SOD1-dependent mechanism seen in familial ALS.<...
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Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2967729
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2967729
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.2660
