Coupling of receptor conformation and ligand orientation determine graded activity
Coupling of receptor conformation and ligand orientation determine graded activity
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
The ability of constrained mutants of the estrogen receptor ligand-binding domain to dictate different conformations of bound partial agonists indicates that the ability of compounds to stabilize each state determines the degree of agonist activity.
Small molecules stabilize specific protein conformations from a larger ensemble, enabling molecul...
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Full title
Coupling of receptor conformation and ligand orientation determine graded activity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2974172
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2974172
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ISSN
1552-4450,1552-4469
E-ISSN
1552-4469
DOI
10.1038/nchembio.451
