Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01
Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01
About this item
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Author / Creator
Zhou, Tongqing , Georgiev, Ivelin , Wu, Xueling , Yang, Zhi-Yong , Dai, Kaifan , Finzi, Andrés , Do Kwon, Young , Scheid, Johannes F , Shi, Wei , Xu, Ling , Yang, Yongping , Zhu, Jiang , Nussenzweig, Michel C , Sodroski, Joseph , Shapiro, Lawrence , Nabel, Gary J , Mascola, John R , Kwong, Peter D and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
United States: American Association for the Advancement of Science
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More information
Scope and Contents
Contents
During HIV-1 infection, antibodies are generated against the region of the viral gp120 envelope glycoprotein that binds CD4, the primary receptor for HIV-1. Among these antibodies, VRC01 achieves broad neutralization of diverse viral strains. We determined the crystal structure of VRC01 in complex with a human immunodeficiency virus HIV-1 gp120 cor...
Alternative Titles
Full title
Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01
Authors, Artists and Contributors
Author / Creator
Georgiev, Ivelin
Wu, Xueling
Yang, Zhi-Yong
Dai, Kaifan
Finzi, Andrés
Do Kwon, Young
Scheid, Johannes F
Shi, Wei
Xu, Ling
Yang, Yongping
Zhu, Jiang
Nussenzweig, Michel C
Sodroski, Joseph
Shapiro, Lawrence
Nabel, Gary J
Mascola, John R
Kwong, Peter D
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2981354
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2981354
Other Identifiers
ISSN
0036-8075,0193-4511
E-ISSN
1095-9203
DOI
10.1126/science.1192819
