Cancer Proliferation Gene Discovery Through Functional Genomics
Cancer Proliferation Gene Discovery Through Functional Genomics
About this item
Full title
Author / Creator
Schlabach, Michael R , Luo, Ji , Solimini, Nicole L , Hu, Guang , Xu, Qikai , Li, Mamie Z , Zhao, Zhenming , Smogorzewska, Agata , Sowa, Mathew E , Ang, Xiaolu L , Westbrook, Thomas F , Liang, Anthony C , Chang, Kenneth , Hackett, Jennifer A , Harper, J. Wade , Hannon, Gregory J and Elledge, Stephen J
Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
Washington, DC: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Retroviral short hairpin RNA (shRNA)-mediated genetic screens in mammalian cells are powerful tools for discovering loss-of-function phenotypes. We describe a highly parallel multiplex methodology for screening large pools of shRNAs using half-hairpin barcodes for microarray deconvolution. We carried out dropout screens for shRNAs that affect cell...
Alternative Titles
Full title
Cancer Proliferation Gene Discovery Through Functional Genomics
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2981870
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2981870
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1149200
