Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain
Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain
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Publisher
Cham: Springer International Publishing
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Language
English
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Publisher
Cham: Springer International Publishing
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Contents
Thiopurine
S
-methyltransferase (TPMT) is the rate-limiting step in the conversion of thiopurine drugs including azathioprine (AZA) to inactive metabolites. Heritable deficiency of TPMT activity increases risk for adverse events, most notably, myelosuppression leading to leukopenia and neutropenic sepsis. The reported European Commission stud...
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Full title
Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2986553
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2986553
Other Identifiers
ISSN
1018-4813
E-ISSN
1476-5438
DOI
10.1038/ejhg.2009.10
