Structural Basis for Activation of Class Ib Ribonucleotide Reductase
Structural Basis for Activation of Class Ib Ribonucleotide Reductase
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Publisher
Washington, DC: American Association for the Advancement of Science
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Language
English
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Publisher
Washington, DC: American Association for the Advancement of Science
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Contents
The class Ib ribonucleotide reductase of Escherichia coli can initiate reduction of nucleotides to deoxynucleotides with either a MnIII₂-tyrosyl radical (Y ) or a FeIII₂-Y cofactor in the NrdF subunit. Whereas FeIII₂-Y can self-assemble from FeII₂-NrdF and O₂, activation of MnII₂-NrdF requires a reduced flavoprotein, NrdI, proposed to form the oxid...
Alternative Titles
Full title
Structural Basis for Activation of Class Ib Ribonucleotide Reductase
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3020666
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3020666
Other Identifiers
ISSN
0036-8075,0193-4511
E-ISSN
1095-9203
DOI
10.1126/science.1190187
