TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to genera...
TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease
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Author / Creator
Lee, M-H , Lin, S-R , Chang, J-Y , Schultz, L , Heath, J , Hsu, L-J , Kuo, Y-M , Hong, Q , Chiang, M-F , Gong, C-X , Sze, C-I and Chang, N-S
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The role of a small transforming growth factor beta (TGF-
β
)-induced TIAF1 (TGF-
β
1-induced antiapoptotic factor) in the pathogenesis of Alzheimer's disease (AD) was investigated. TIAF1 physically interacts with mothers against DPP homolog 4 (Smad4), and blocks SMAD-dependent promoter activation when overexpressed. Accordingly, knockd...
Alternative Titles
Full title
TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3032296
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3032296
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/cddis.2010.83
