Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca²⁺ cross-talk
Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca²⁺ cross-talk
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Presenilin mutations are the main cause of familial Alzheimer's disease (FAD). Presenilins also play a key role in Ca²⁺ homeostasis, and their FAD-linked mutants affect cellular Ca²⁺ handling in several ways. We previously have demonstrated that FAD-linked presenilin 2 (PS2) mutants decrease the Ca²⁺ content of the endoplasmic reticulum (ER) by inh...
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Full title
Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca²⁺ cross-talk
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3041131
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3041131
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1100735108
