Enhanced ROS generation mediated by Alzheimer's disease presenilin regulation of InsP3R Ca2+ signali...
Enhanced ROS generation mediated by Alzheimer's disease presenilin regulation of InsP3R Ca2+ signaling
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Author / Creator
Publisher
United States: Mary Ann Liebert, Inc
Journal title
Language
English
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Publisher
United States: Mary Ann Liebert, Inc
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Scope and Contents
Contents
Familial Alzheimer's disease (FAD) is caused by mutations in amyloid precursor protein and presenilins (PS1, PS2). Many FAD-linked PS mutations affect intracellular calcium (Ca(2+)) homeostasis by proximal mechanisms independent of amyloid production by dramatically enhancing gating of the inositol trisphosphate receptor (InsP(3)R) intracellular Ca...
Alternative Titles
Full title
Enhanced ROS generation mediated by Alzheimer's disease presenilin regulation of InsP3R Ca2+ signaling
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3048838
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3048838
Other Identifiers
ISSN
1523-0864
E-ISSN
1557-7716
DOI
10.1089/ars.2010.3421
