The histone variant macroH2A suppresses melanoma progression through regulation of CDK8
The histone variant macroH2A suppresses melanoma progression through regulation of CDK8
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Histone variant lost in melanoma progression
The histone variant mH2A is shown to be expressed at reduced levels in many melanomas. Loss of mH2A promotes tumour growth and metastasis, by transcriptional upregulation of CDK8, a known oncogene. This study therefore reveals a new tumour-suppression mechanism exerted by chromatin modification.
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Full title
The histone variant macroH2A suppresses melanoma progression through regulation of CDK8
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3057940
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3057940
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature09590
