Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca²⁺ fluxes in oxidative cell death
Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca²⁺ fluxes in oxidative cell death
About this item
Full title
Author / Creator
Blenn, C , Wyrsch, P , Bader, J , Bollhalder, M and Althaus, Felix R
Publisher
Basel: Basel : SP Birkhäuser Verlag Basel
Journal title
Language
English
Formats
Publication information
Publisher
Basel: Basel : SP Birkhäuser Verlag Basel
Subjects
More information
Scope and Contents
Contents
Oxidative DNA damage to cells activates poly(ADP-ribose)polymerase-1 (PARP-1) and the poly(ADP-ribose) formed is rapidly degraded to ADP-ribose by poly(ADP-ribose)glycohydrolase (PARG). Here we show that PARP-1 and PARG control extracellular Ca²⁺ fluxes through melastatin-like transient receptor potential 2 channels (TRPM2) in a cell death signalin...
Alternative Titles
Full title
Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca²⁺ fluxes in oxidative cell death
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3064896
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3064896
Other Identifiers
ISSN
1420-682X
E-ISSN
1420-9071
DOI
10.1007/s00018-010-0533-1
