Presynaptic CLC-3 determines quantal size of inhibitory transmission in the hippocampus
Presynaptic CLC-3 determines quantal size of inhibitory transmission in the hippocampus
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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The authors report that the chloride channel CLC-3 colocalizes with the vesicular GABA transporter VGAT in the CA1 region of the hippocampus, where it affected Cl
−
-induced acidification of synaptic vesicles.
Clcn3
−/−
animals showed a decrement in inhibitory transmission, suggesting a decrease in neurotransmitter loading of synapti...
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Full title
Presynaptic CLC-3 determines quantal size of inhibitory transmission in the hippocampus
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3072292
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3072292
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.2775
