Single-molecule analysis reveals the molecular bearing mechanism of DNA strand exchange by a serine...
Single-molecule analysis reveals the molecular bearing mechanism of DNA strand exchange by a serine recombinase
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Structural and topological data suggest that serine site-specific DNA recombinases exchange duplex DNAs by rigid-body relative rotation of the two halves of the synapse, mediated by a flat protein-protein interaction surface. We present evidence for this rotational motion for a simple serine recombinase, the Bxb1 phage integrase, from a single-DNA-...
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Full title
Single-molecule analysis reveals the molecular bearing mechanism of DNA strand exchange by a serine recombinase
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3088605
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3088605
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1018436108
