The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
About this item
Full title
Author / Creator
Chowdhury, Rasheduzzaman , Yeoh, Kar Kheng , Tian, Ya-Min , Hillringhaus, Lars , Bagg, Eleanor A , Rose, Nathan R , Leung, Ivanhoe K H , Li, Xuan S , Woon, Esther C Y , Yang, Ming , McDonough, Michael A , King, Oliver N , Clifton, Ian J , Klose, Robert J , Claridge, Timothy D W , Ratcliffe, Peter J , Schofield, Christopher J and Kawamura, Akane
Publisher
Chichester, UK: John Wiley & Sons, Ltd
Journal title
Language
English
Formats
Publication information
Publisher
Chichester, UK: John Wiley & Sons, Ltd
Subjects
More information
Scope and Contents
Contents
Mutations in isocitrate dehydrogenases (IDHs) have a gain‐of‐function effect leading to
R
(−)‐2‐hydroxyglutarate (
R‐
2HG) accumulation. By using biochemical, structural and cellular assays, we show that either or both
R
‐ and
S
‐2HG inhibit 2‐oxoglutarate (2OG)‐dependent oxygenases with varying potencies. Half‐maximal inhib...
Alternative Titles
Full title
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
Authors, Artists and Contributors
Author / Creator
Yeoh, Kar Kheng
Tian, Ya-Min
Hillringhaus, Lars
Bagg, Eleanor A
Rose, Nathan R
Leung, Ivanhoe K H
Li, Xuan S
Woon, Esther C Y
Yang, Ming
McDonough, Michael A
King, Oliver N
Clifton, Ian J
Klose, Robert J
Claridge, Timothy D W
Ratcliffe, Peter J
Schofield, Christopher J
Kawamura, Akane
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3090014
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3090014
Other Identifiers
ISSN
1469-221X
E-ISSN
1469-3178
DOI
10.1038/embor.2011.43
