The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice
The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice
About this item
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Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Vectors based on adeno-associated virus (AAV) serotype 9 are candidates for in vivo gene delivery to many organs, but the receptor(s) mediating these tropisms have yet to be defined. We evaluated AAV9 uptake by glycans with terminal sialic acids (SAs), a common mode of cellular entry for viruses. We found, however, that AAV9 binding increased when...
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Full title
The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3104778
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3104778
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI57367
