SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS produc...
SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production
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Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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It has become increasing clear that alterations in cellular metabolism have a key role in the generation and maintenance of cancer. Some of the metabolic changes can be attributed to the activation of oncogenes or loss of tumor suppressors. Here, we show that the mitochondrial sirtuin, SirT3, acts as a tumor suppressor via its ability to suppress r...
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Full title
SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3134877
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3134877
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/onc.2011.37
