A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sc...
A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility
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Author / Creator
Bush, W S , McCauley, J L , DeJager, P L , Dudek, S M , Hafler, D A , Gibson, R A , Matthews, P M , Kappos, L , Naegelin, Y , Polman, C H , Hauser, S L , Oksenberg, J , Haines, J L , Ritchie, M D , the International Multiple Sclerosis Genetics Consortium and International Multiple Sclerosis Genetics Consortium
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Gene–gene interactions are proposed as an important component of the genetic architecture of complex diseases, and are just beginning to be evaluated in the context of genome-wide association studies (GWAS). In addition to detecting epistasis, a benefit to interaction analysis is that it also increases power to detect weak main effects. We conducte...
Alternative Titles
Full title
A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3136581
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3136581
Other Identifiers
ISSN
1466-4879
E-ISSN
1476-5470
DOI
10.1038/gene.2011.3
