Small-molecule hydrophobic tagging–induced degradation of HaloTag fusion proteins
Small-molecule hydrophobic tagging–induced degradation of HaloTag fusion proteins
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Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
A search through hydrophobic chemical space identifies an adamantane tag that targets dehalogenase fusion proteins for degradation, as demonstrated for both cytosolic and transmembrane proteins; and in zebrafish and mice. This molecule provides a new tool to study protein function with precise control.
The ability to regulate any protein of inte...
Alternative Titles
Full title
Small-molecule hydrophobic tagging–induced degradation of HaloTag fusion proteins
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3139752
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3139752
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.597
