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Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-κB-dependent gene transcript...

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-κB-dependent gene transcript...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_314216

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-κB-dependent gene transcription

About this item

Full title

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-κB-dependent gene transcription

Publisher

Chichester, UK: John Wiley & Sons, Ltd

Journal title

The EMBO journal, 2000-09, Vol.19 (18), p.4976-4985

Language

English

Formats

Publication information

Publisher

Chichester, UK: John Wiley & Sons, Ltd

More information

Scope and Contents

Contents

Induction of NF‐κB‐dependent transcription requires phosphorylation and subsequent degradation of I‐κB, an inhibitor of NF‐κB, followed by nuclear translocation and DNA binding of NF‐κB. Tumor necrosis factor receptor‐associated factor 2 (TRAF2) plays a role in NF‐κB activation in response to cytokines such as tumor necrosis factor α (TNFα). In thi...

Alternative Titles

Full title

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-κB-dependent gene transcription

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_314216

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_314216

Other Identifiers

ISSN

0261-4189

E-ISSN

1460-2075

DOI

10.1093/emboj/19.18.4976

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