Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination
Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination
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New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Premyelinating oligodendrocytes are vulnerable to hypoxic injuries, especially during the neonatal period. Here, Fancy
et al
. find that the Wnt scaffolding molecule Axin2 is crucial for normal remyelination after hypoxic injuries and demonstrate that pharmacological inhibition of tankyrase, which stabilizes Axin2 levels, can promote oligoden...
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Full title
Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3145042
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3145042
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.2855
