Production of α1,3-Galactosyltransferase: Deficient Pigs
Production of α1,3-Galactosyltransferase: Deficient Pigs
About this item
Full title
Author / Creator
Phelps, Carol J. , Koike, Chihiro , Vaught, Todd D. , Boone, Jeremy , Wells, Kevin D. , Chen, Shu-Hung , Ball, Suyapa , Specht, Susan M. , Polejaeva, Irina A. , Monahan, Jeff A. , Jobst, Pete M. , Sharma, Sugandha B. , Lamborn, Ashley E. , Garst, Amy S. , Moore, Marilyn , Demetris, Anthony J. , Rudert, William A. , Bottino, Rita , Bertera, Suzanne , Trucco, Massimo , Starzl, Thomas E. , Dai, Yifan and Ayares, David L.
Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
Washington, DC: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
The enzyme α1,3-galactosyltransferase (α1,3GT or GGTA1) synthesizes α1,3-galactose (α1,3Gal) epitopes (Galα1,3Galβ1,4GlcNAc-R), which are the major xenoantigens causing hyperacute rejection in pig-to-human xenotransplantation. Complete removal of α1,3Gal from pig organs is the critical step toward the success of xenotransplantation. We reported ear...
Alternative Titles
Full title
Production of α1,3-Galactosyltransferase: Deficient Pigs
Authors, Artists and Contributors
Author / Creator
Koike, Chihiro
Vaught, Todd D.
Boone, Jeremy
Wells, Kevin D.
Chen, Shu-Hung
Ball, Suyapa
Specht, Susan M.
Polejaeva, Irina A.
Monahan, Jeff A.
Jobst, Pete M.
Sharma, Sugandha B.
Lamborn, Ashley E.
Garst, Amy S.
Moore, Marilyn
Demetris, Anthony J.
Rudert, William A.
Bottino, Rita
Bertera, Suzanne
Trucco, Massimo
Starzl, Thomas E.
Dai, Yifan
Ayares, David L.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3154759
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3154759
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1078942
