Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC
Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Astrocytes regulate synaptic connectivity in the CNS through secreted signals. Here we identified two astrocyte-secreted proteins, hevin and SPARC, as regulators of excitatory synaptogenesis in vitro and in vivo. Hevin induces the formation of synapses between cultured rat retinal ganglion cells. SPARC is not synaptogenic, but specifically antagoni...
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Full title
Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3156217
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3156217
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1104977108
