Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung dis...
Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans
About this item
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Author / Creator
Ngan, Elly Sau-Wai , Garcia-Barceló, Maria-Mercè , Yip, Benjamin Hon-Kei , Poon, Hiu-Ching , Lau, Sin-Ting , Kwok, Carmen Ka-Man , Sat, Eric , Sham, Mai-Har , Wong, Kenneth Kak-Yuen , Wainwright, Brandon J. , Cherny, Stacey S. , Hui, Chi-Chung , Sham, Pak Chung , Lui, Vincent Chi-Hang and Tam, Paul Kwong-Hang
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publication information
Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
Hirschsprung (HSCR) disease is a complex genetic disorder attributed to a failure of the enteric neural crest cells (ENCCs) to form ganglia in the hindgut. Hedgehog and Notch are implicated in mediating proliferation and differentiation of ENCCs. Nevertheless, how these signaling molecules may interact to mediate gut colonization by ENCCs and contr...
Alternative Titles
Full title
Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3163945
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3163945
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI43737
