Selective modification of HK peptides enhances siRNA silencing of tumor targets in vivo
Selective modification of HK peptides enhances siRNA silencing of tumor targets in vivo
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Author / Creator
Chou, S-T , Leng, Q , Scaria, P , Woodle, M and Mixson, A J
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Our research has focused on systemic delivery of small interference RNA (siRNA) by branched peptides composed of histidine and lysine. After studying several histidine-lysine (HK) peptides, one four-branched peptide, H3K(+H)4b, with a predominant repeating pattern of -HHHK-, was found to be an effective carrier of siRNA. Although the unmodified H3K...
Alternative Titles
Full title
Selective modification of HK peptides enhances siRNA silencing of tumor targets in vivo
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3177007
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3177007
Other Identifiers
ISSN
0929-1903
E-ISSN
1476-5500
DOI
10.1038/cgt.2011.40
