The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase
The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Taking PAR apart
Proteins can be reversibly modified through the addition of repeating, polymerized ADP-ribose (PAR) subunits catalysed by poly(ADP-ribose) polymerase (PARP). Removal of PAR requires a glycohydrolase (PARG), which cleaves the ribose–ribose bond between subunits. Ivan Ahel and colleagues report that bacteria and fungi have a diver...
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The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3184140
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3184140
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature10404
