Specificity and detection of insulin-reactive CD4⁺ T cells in type 1 diabetes in the nonobese diabet...
Specificity and detection of insulin-reactive CD4⁺ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
In the nonobese diabetic (NOD) mouse model of type 1 diabetes (T1D), an insulin peptide (B:9-23) is a major target for pathogenic CD4⁺ T cells. However, there is no consensus on the relative importance of the various positions or "registers" this peptide can take when bound in the groove of the NOD MHCII molecule, IAg⁷. This has hindered structural...
Alternative Titles
Full title
Specificity and detection of insulin-reactive CD4⁺ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3189014
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3189014
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1113954108
