The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hype...
The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension
About this item
Full title
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Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Calcineurin inhibitors, such as tacrolimus, are widely used immunosuppressive agents, but they can cause hypertension. In studies of tacrolimus-treated mice, the authors show that hypertension is due to activation of the sodium chloride transporter NCC in the kidney, causing sodium retention. They found that NCC activation also occurred in kidney t...
Alternative Titles
Full title
The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3192268
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3192268
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2497
