EP4 receptor stimulation down-regulates human eosinophil function
EP4 receptor stimulation down-regulates human eosinophil function
About this item
Full title
Author / Creator
Publisher
Basel: SP Birkhäuser Verlag Basel
Journal title
Language
English
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Publication information
Publisher
Basel: SP Birkhäuser Verlag Basel
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Scope and Contents
Contents
Accumulation of eosinophils in tissue is a hallmark of allergic inflammation. Here we observed that a selective agonist of the PGE
2
receptor EP4, ONO AE1-329, potently attenuated the chemotaxis of human peripheral blood eosinophils, upregulation of the adhesion molecule CD11b and the production of reactive oxygen species. These effects were...
Alternative Titles
Full title
EP4 receptor stimulation down-regulates human eosinophil function
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3192285
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3192285
Other Identifiers
ISSN
1420-682X
E-ISSN
1420-9071
DOI
10.1007/s00018-011-0642-5
