A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans
A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans
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Publisher
United States: American Society for Clinical Investigation
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Language
English
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Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
Proteasomes are multisubunit proteases that play a critical role in maintaining cellular function through the selective degradation of ubiquitinated proteins. When 3 additional β subunits, expression of which is induced by IFN-γ, are substituted for their constitutively expressed counterparts, the structure is converted to an immunoproteasome. Howe...
Alternative Titles
Full title
A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3195477
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3195477
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI58414
