iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia
iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia
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Author / Creator
Chikh, Anissa , Matin, Rubeta N H , Senatore, Valentina , Hufbauer, Martin , Lavery, Danielle , Raimondi, Claudio , Ostano, Paola , Mello-Grand, Maurizia , Ghimenti, Chiara , Bahta, Adiam , Khalaf, Sahira , Akgül, Baki , Braun, Kristin M , Chiorino, Giovanna , Philpott, Michael P , Harwood, Catherine A and Bergamaschi, Daniele
Publisher
Chichester, UK: John Wiley & Sons, Ltd
Journal title
Language
English
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Publication information
Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Scope and Contents
Contents
iASPP, an inhibitory member of the ASPP (apoptosis stimulating protein of p53) family, is an evolutionarily conserved inhibitor of p53 which is frequently upregulated in human cancers. However, little is known about the role of iASPP under physiological conditions. Here, we report that iASPP is a critical regulator of epithelial development. We dem...
Alternative Titles
Full title
iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3199390
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3199390
Other Identifiers
ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/emboj.2011.302
