Log in to save to my catalogue
Log in to save to my catalogue

Dual inhibition of SRC and Aurora kinases induces post-mitotic attachment defects and cell death

| Ask | Become a Library member

Dual inhibition of SRC and Aurora kinases induces post-mitotic attachment defects and cell death

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3204164

Dual inhibition of SRC and Aurora kinases induces post-mitotic attachment defects and cell death

About this item

Full title

Dual inhibition of SRC and Aurora kinases induces post-mitotic attachment defects and cell death

Author / Creator

Ratushny, Vladimir , Pathak, Harsh B , Beeharry, Neil , Tikhmyanova, Nadezhda , Xiao, Fang , Li, Tianyu , Litwin, Samuel , Connolly, Denise C. , Yen, Timothy J. , Weiner, Louis M. , Godwin, Andrew K. and Golemis, Erica A.

Journal title

Oncogene, 2011-07, Vol.31 (10), p.1217-1227

Language

English

Formats

Articles

More information

Scope and Contents

Contents

Increased activity of SRC family kinases promotes tumor invasion and metastasis, and overexpression of the mitotic regulator Aurora kinase A (AURKA) drives tumor aneuploidy and chromosomal instability. These actions nominate SRC and AURKA as valuable therapeutic targets for cancer, and inhibitors for SRC and Aurora kinases are now being employed in...

Alternative Titles

Full title

Dual inhibition of SRC and Aurora kinases induces post-mitotic attachment defects and cell death

Authors, Artists and Contributors

Author / Creator

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3204164

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3204164

Other Identifiers

ISSN

0950-9232

E-ISSN

1476-5594

DOI

10.1038/onc.2011.314

How to access this item

Log in as a Library member

Full text available

View in old catalogue

Connecting people and collections