Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase
Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase
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Author / Creator
Du, Jintang , Zhou, Yeyun , Su, Xiaoyang , Yu, Jiu Jiu , Khan, Saba , Jiang, Hong , Kim, Jungwoo , Woo, Jimin , Kim, Jun Huyn , Choi, Brian Hyun , He, Bin , Chen, Wei , Zhang, Sheng , Cerione, Richard A. , Auwerx, Johan , Hao, Quan and Lin, Hening
Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
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Publisher
Washington, DC: American Association for the Advancement of Science
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Contents
Silent information regulator 2 (Sir2) proteins (sirtuins) are nicotinamide adenine dinucleotidedependent deacetylases that regulate important biological processes. Mammals have seven sirtuins, Sirt1 to Sirt7. Four of them (Sirt4 to Sirt7) have no detectable or very weak deacetylase activity. We found that Sirt5 is an efficient protein lysine desucc...
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Full title
Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3217313
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3217313
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1207861
