IL-21 Is an Antitolerogenic Cytokine of the Late-Phase Alloimmune Response
IL-21 Is an Antitolerogenic Cytokine of the Late-Phase Alloimmune Response
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Author / Creator
Petrelli, Alessandra , Carvello, Michele , Vergani, Andrea , Lee, Kang Mi , Tezza, Sara , Du, Ming , Kleffel, Sonja , Chengwen, Liu , Mfarrej, Bechara G. , Hwu, Patrick , Secchi, Antonio , Leonard, Warren J. , Young, Deborah , Sayegh, Mohamed H. , Markmann, James F. , Zajac, Allan J. and Fiorina, Paolo
Publisher
Alexandria, VA: American Diabetes Association
Journal title
Language
English
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Publisher
Alexandria, VA: American Diabetes Association
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Scope and Contents
Contents
Interleukin-21 (IL-21) is a proinflammatory cytokine that has been shown to affect Treg/Teff balance. However, the mechanism by which IL-21 orchestrates alloimmune response and interplays with Tregs is still unclear.
The interplay between IL-21/IL-21R signaling, FoxP3 expression, and Treg survival and function was evaluated in vitro in immunolog...
Alternative Titles
Full title
IL-21 Is an Antitolerogenic Cytokine of the Late-Phase Alloimmune Response
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3219943
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3219943
Other Identifiers
ISSN
0012-1797
E-ISSN
1939-327X
DOI
10.2337/db11-0880
