Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells
Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells
About this item
Full title
Author / Creator
Wang, J , Anderson, P D , Luo, W , Gius, D , Roh, M and Abdulkadir, S A
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
PIM1 kinase and MYC are commonly co-expressed in human prostate cancer and synergize to induce rapidly progressing prostate cancer in mouse models. Deficiency of the
Pim
kinase genes is well tolerated
in vivo
, suggesting that PIM1 inhibition might offer an attractive therapeutic modality for prostate cancer, particularly for MYC-expres...
Alternative Titles
Full title
Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3223544
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3223544
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/onc.2011.371
