Absence of Stat1 in donor CD4+ T cells promotes the expansion of Tregs and reduces graft-versus-host...
Absence of Stat1 in donor CD4+ T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice
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United States: American Society for Clinical Investigation
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Language
English
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United States: American Society for Clinical Investigation
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STAT1 is the main signal transducer for type I and II IFNs and plays a central role in the regulation of innate and adaptive immune responses. We used Stat1-deficient mice to test the role of donor Stat1 in MHC-matched minor histocompatibility antigen-mismatched (mHA-mismatched) and fully MHC-mismatched models of bone marrow transplantation. Lack o...
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Full title
Absence of Stat1 in donor CD4+ T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3223821
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3223821
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ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI43706
