PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein
PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein
About this item
Full title
Author / Creator
Li, C G , Nyman, J E , Braithwaite, A W and Eccles, M R
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The retinoblastoma protein (RB)–E2F1 pathway has a central role in regulating the cell cycle. Several PAX proteins (tissue-specific developmental regulators), including PAX8, interact with the RB protein, and thus regulate the cell cycle directly or indirectly. Here, we report that PAX8 expression is frequent in renal cell carcinoma, bladder, ovari...
Alternative Titles
Full title
PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3229668
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3229668
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/onc.2011.190
