miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA
miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
MicroRNAs (miRNAs) are ∼22 nt non‐coding RNAs that typically bind to the 3′ UTR of target mRNAs in the cytoplasm, resulting in mRNA destabilization and translational repression. Here, we report that miRNAs can also regulate gene expression by targeting non‐coding antisense transcripts in human cells. Specifically, we show that miR‐671 directs cleav...
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Full title
miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3230379
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3230379
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ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/emboj.2011.359
