Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
About this item
Full title
Author / Creator
Yang, Weiwei , Xia, Yan , Ji, Haitao , Zheng, Yanhua , Liang, Ji , Huang, Wenhua , Gao, Xiang , Aldape, Kenneth and Lu, Zhimin
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The embryonic pyruvate kinase M2 (PKM2) isoform is highly expressed in human cancer. In contrast to the established role of PKM2 in aerobic glycolysis or the Warburg effect
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, its non-metabolic functions remain elusive. Here we demonstrate, in human cancer cells, that epidermal growth factor receptor (EGFR) activation ind...
Alternative Titles
Full title
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3235705
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3235705
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature10598
