Mapping intact protein isoforms in discovery mode using top-down proteomics
Mapping intact protein isoforms in discovery mode using top-down proteomics
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Author / Creator
Tran, John C. , Zamdborg, Leonid , Ahlf, Dorothy R. , Lee, Ji Eun , Catherman, Adam D. , Durbin, Kenneth R. , Tipton, Jeremiah D. , Vellaichamy, Adaikkalam , Kellie, John F. , Li, Mingxi , Wu, Cong , Sweet, Steve M. M. , Early, Bryan P. , Siuti, Nertila , LeDuc, Richard D. , Compton, Philip D. , Thomas, Paul M. and Kelleher, Neil L.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Intact proteins yield to proteomics
Conventional 'bottom-up' proteomics, in which mass spectrometry is used to analyse peptide mixtures made by tryptic digestion of target proteins, is a powerful way of characterizing complex proteomes. However, the technique has limitations when considering different protein isoforms and combinations of post-tr...
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Full title
Mapping intact protein isoforms in discovery mode using top-down proteomics
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3237778
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3237778
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature10575
