The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation
The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
The generation of reactive oxygen species needs to be carefully controlled to prevent tissue injury. Malik and colleagues identify a negative feedback mechanism for such production involving the cation channel TRPM2.
The NADPH oxidase activity of phagocytes and its generation of reactive oxygen species (ROS) is critical for host defense, but ROS...
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Full title
The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3242890
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3242890
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni.2171
