Regulation of p53 stability and function by the deubiquitinating enzyme USP42
Regulation of p53 stability and function by the deubiquitinating enzyme USP42
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
Journal title
Language
English
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Scope and Contents
Contents
The p53 tumour suppressor protein is a transcription factor that prevents oncogenic progression by activating the expression of apoptosis and cell‐cycle arrest genes in stressed cells. The stability of p53 is tightly regulated by ubiquitin‐dependent degradation, driven mainly by the ubiquitin ligase MDM2. In this study, we have identified USP42 as...
Alternative Titles
Full title
Regulation of p53 stability and function by the deubiquitinating enzyme USP42
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3243628
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3243628
Other Identifiers
ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/emboj.2011.419
