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Floor plate-derived dopamine neurons from hESCs efficiently engraft in animal models of PD

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Floor plate-derived dopamine neurons from hESCs efficiently engraft in animal models of PD

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3245796

Floor plate-derived dopamine neurons from hESCs efficiently engraft in animal models of PD

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Full title

Floor plate-derived dopamine neurons from hESCs efficiently engraft in animal models of PD

Author / Creator

Kriks, Sonja , Shim, Jae-Won , Piao, Jinghua , Ganat, Yosif M. , Wakeman, Dustin R. , Xie, Zhong , Carrillo-Reid, Luis , Auyeung, Gordon , Antonacci, Chris , Buch, Amanda , Yang, Lichuan , Beal, M. Flint , Surmeier, D. James , Kordower, Jeffrey H. , Tabar, Viviane and Studer, Lorenz

Journal title

Nature (London), 2011-11, Vol.480 (7378), p.547-551

Language

English

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Articles

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Scope and Contents

Contents

Human pluripotent stem cells (hPSCs) are a promising source of cells for applications in regenerative medicine. Directed differentiation of hPSCs into specialized cells such as spinal motoneurons
1
or midbrain dopamine (DA) neurons
2
has been achieved. However, the effective use of hPSCs for cell therapy has lagged behind. While mouse P...

Alternative Titles

Full title

Floor plate-derived dopamine neurons from hESCs efficiently engraft in animal models of PD

Authors, Artists and Contributors

Author / Creator

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Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3245796

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3245796

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature10648

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