PRDM1 is a tumor suppressor gene in natural killer cell malignancies
PRDM1 is a tumor suppressor gene in natural killer cell malignancies
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Natural killer cell lymphoma (NKCL) constitutes a rare and aggressive form of non-Hodgkin lymphoma, and there is little insight into its pathogenesis. Here we show that PRDM1 is a tumor suppressor gene in NKCLs that is inactivated by a combination of monoallelic deletion and promoter CpG island hypermethylation. We observed monoallelic deletion of...
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Full title
PRDM1 is a tumor suppressor gene in natural killer cell malignancies
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3250125
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3250125
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1115128108
