Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery
Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery
About this item
Full title
Author / Creator
Kovacs, J R , Li, C , Yang, Q , Li, G , Garcia, I G , Ju, S , Roodman, D G , Windle, J J , Zhang, X and Lu, B
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Autophagy is implicated in regulating cell death in activated T cells, but the underlying mechanism is unclear. Here, we show that inhibition of autophagy via Beclin 1 gene deletion in T cells leads to rampant apoptosis in these cells upon TCR stimulation. Beclin 1-deficient mice fail to mount autoreactive T-cell responses and are resistant to expe...
Alternative Titles
Full title
Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3252822
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3252822
Other Identifiers
ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/cdd.2011.78
