Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
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Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Pancreatic cancer is almost invariably associated with mutations in the KRAS gene, most commonly KRASG12D, that result in a dominant-active form of the KRAS GTPase. However, how KRAS mutations promote pancreatic carcinogenesis is not fully understood, and whether oncogenic KRAS is required for the maintenance of pancreatic cancer has not been estab...
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Full title
Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3266788
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3266788
Other Identifiers
ISSN
0021-9738,1558-8238
E-ISSN
1558-8238
DOI
10.1172/JCI59227
