Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sen...
Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor
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Author / Creator
Sugihara, E , Shimizu, T , Kojima, K , Onishi, N , Kai, K , Ishizawa, J , Nagata, K , Hashimoto, N , Honda, H , Kanno, M , Miwa, M , Okada, S , Andreeff, M and Saya, H
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The cell of origin of tumors and the factors determining the cell of origin remain unclear. In this study, a mouse model of precursor B acute lymphoblastic leukemia/lymphoma (pre-B ALL/LBL) was established by retroviral transduction of
Myc
genes (
N-Myc
or
c-Myc
) into mouse bone marrow cells. Hematopoietic stem cells (HSCs) exhib...
Alternative Titles
Full title
Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3271180
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3271180
Other Identifiers
ISSN
0950-9232,1476-5594
E-ISSN
1476-5594
DOI
10.1038/onc.2011.462
