AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation
AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation
About this item
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Author / Creator
Lanner, Johanna T , Georgiou, Dimitra K , Dagnino-Acosta, Adan , Ainbinder, Alina , Cheng, Qing , Joshi, Aditya D , Chen, Zanwen , Yarotskyy, Viktor , Oakes, Joshua M , Lee, Chang Seok , Monroe, Tanner O , Santillan, Arturo , Dong, Keke , Goodyear, Laurie , Ismailov, Iskander I , Rodney, George G , Dirksen, Robert T and Hamilton, Susan L
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Mutations in the type I ryanodine receptor (RYR1), a calcium channel, leads to stimulus-induced pathological muscle contractions, including malignant hyperthermia. Currently there are no pharmacological agents to protect against this condition, but Susan Hamilton and her colleagues have now identified AICAR as one possible candidate compound. To da...
Alternative Titles
Full title
AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation
Authors, Artists and Contributors
Author / Creator
Georgiou, Dimitra K
Dagnino-Acosta, Adan
Ainbinder, Alina
Cheng, Qing
Joshi, Aditya D
Chen, Zanwen
Yarotskyy, Viktor
Oakes, Joshua M
Lee, Chang Seok
Monroe, Tanner O
Santillan, Arturo
Dong, Keke
Goodyear, Laurie
Ismailov, Iskander I
Rodney, George G
Dirksen, Robert T
Hamilton, Susan L
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3274651
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3274651
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2598
