Host S-nitrosylation inhibits clostridial small molecule–activated glucosylating toxins
Host S-nitrosylation inhibits clostridial small molecule–activated glucosylating toxins
About this item
Full title
Author / Creator
Savidge, Tor C , Urvil, Petri , Oezguen, Numan , Ali, Kausar , Choudhury, Aproteem , Acharya, Vinay , Pinchuk, Irina , Torres, Alfredo G , English, Robert D , Wiktorowicz, John E , Loeffelholz, Michael , Kumar, Raj , Shi, Lianfa , Nie, Weijia , Braun, Werner , Herman, Bo , Hausladen, Alfred , Feng, Hanping , Stamler, Jonathan S and Pothoulakis, Charalabos
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Clostridium difficile
causes serious intestinal illness mediated by two exotoxins, TcdA and TcdB. In this issue, Savidge
et al
. report that these toxins can be modified by S-nitrosothiol, resulting in their impaired enzymatic activity
in vitro
and reduced disease in mice. Their findings suggest that promoting S-nitrosylation of
C...
Alternative Titles
Full title
Host S-nitrosylation inhibits clostridial small molecule–activated glucosylating toxins
Authors, Artists and Contributors
Author / Creator
Urvil, Petri
Oezguen, Numan
Ali, Kausar
Choudhury, Aproteem
Acharya, Vinay
Pinchuk, Irina
Torres, Alfredo G
English, Robert D
Wiktorowicz, John E
Loeffelholz, Michael
Kumar, Raj
Shi, Lianfa
Nie, Weijia
Braun, Werner
Herman, Bo
Hausladen, Alfred
Feng, Hanping
Stamler, Jonathan S
Pothoulakis, Charalabos
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3277400
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3277400
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2405
