A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield
A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield
About this item
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Author / Creator
Pejchal, Robert , Doores, Katie J. , Walker, Laura M. , Khayat, Reza , Huang, Po-Ssu , Wang, Sheng-Kai , Stanfield, Robyn L. , Julien, Jean-Philippe , Ramos, Alejandra , Crispin, Max , Depetris, Rafael , Katpally, Umesh , Marozsan, Andre , Cupo, Albert , Maloveste, Sebastien , Liu, Yan , McBride, Ryan , Ito, Yukishige , Sanders, Rogier W. , Ogohara, Cassandra , Paulson, James C. , Feizi, Ten , Scanlan, Christopher N. , Wong, Chi-Huey , Moore, John P. , Olson, William C. , Ward, Andrew B. , Poignard, Pascal , Schief, William R. , Burton, Dennis R. , Wilson, Ian A. and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
Washington, DC: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
The HIV envelope (Env) protein gpl20 is protected from antibody recognition by a dense glycan shield. However, several of the recently identified PGT broadly neutralizing antibodies appear to interact directly with the HIV glycan coat. Crystal structures of antigen-binding fragments (Fabs) PGT 127 and 128 with Man 9 at 1.65 and 1.29 angstrom resolu...
Alternative Titles
Full title
A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield
Authors, Artists and Contributors
Author / Creator
Doores, Katie J.
Walker, Laura M.
Khayat, Reza
Huang, Po-Ssu
Wang, Sheng-Kai
Stanfield, Robyn L.
Julien, Jean-Philippe
Ramos, Alejandra
Crispin, Max
Depetris, Rafael
Katpally, Umesh
Marozsan, Andre
Cupo, Albert
Maloveste, Sebastien
Liu, Yan
McBride, Ryan
Ito, Yukishige
Sanders, Rogier W.
Ogohara, Cassandra
Paulson, James C.
Feizi, Ten
Scanlan, Christopher N.
Wong, Chi-Huey
Moore, John P.
Olson, William C.
Ward, Andrew B.
Poignard, Pascal
Schief, William R.
Burton, Dennis R.
Wilson, Ian A.
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3280215
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3280215
Other Identifiers
ISSN
0036-8075,0193-4511
E-ISSN
1095-9203
DOI
10.1126/science.1213256
